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MPA is primarily metabolized by uridine 5-diphospho-glucuronosyltransferases (UGTs) to form the abundant but inactive 7-O-mycophenolic acid glucuronide (MPAG) and the relatively minor but active acyl-glucuronide MPA ( via multidrug resistance-associated protein 2 (MRP2, gene symbol ABCC2) and breast cancer resistance protein (BCRP, gene symbol ABCG2) ( A 10-fold variation in MPA exposure has been observed even in patients who were administered a similar dose during the first 2 weeks after kidney transplantation

Ampofo J, Abbey L

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Antioxidants shield cells from harmful and unstable molecules by employing processes that eliminate them, thus preventing the oxidation of endogenous or non-endogenous molecules

Both compounds require precise weekly dosing rather than daily administration